Bases neurobiológicas y clínicas de la dependencia a opiáceos

PINEDA-ORTIZ, Joseba

Publication year:

2001

Publication place:

Donostia-San Sebastián

ISSN:

1577-8533

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Summary

The article intends to deepen in the neurochemical and neurophisiological mechanisms that underlie in the dependency to opiates. Opium and opiate derivatives have been employed for centuries for therapeutic purposes, but they have also been the origin of a serious social and personal problem: dependency. According to research accomplished over the last decades, dependency to opiates is produced by the stimulation of opioid µ receivers and by the activation of certain systems of neurotransmission like the noradrenergic and the dopaminergic systems.